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IGF-II is thought to be a primary growth factor required for development while IGF-I expression is seen in later life. Gene knockout studies in mice have confirmed this though other animals are likely to regulate the expression of these genes in distinct ways. While IGF-II may be primarily fetal in action it is also essential for development and function of organs such as the brain, liver and kidney. IGF-I is mainly secreted by the liver as a result of stimulation by Human Growth Hormone (hGH). Almost every cell in the human body is affected by IGF-I, especially cells in muscle, cartilage, value. Every cell is capable of producing a vast number of regulatory molecules - tissue hormones, neurotransmitters, cytokines and many more. The classical endocrine glands and their hormone products are only better specialized to serve regulation on the overall organism level. Nevertheless they can in many instances be used in other ways or only on the tissue level. The most important hormones in humans include: adrenaline - synonymous with epinephrine adrenocorticotropic hormone (ACTH) aldosterone angiotensinogen antidiuretic hormone (ADH) atrial-natriuretic peptide (ANP) calciferol (vitamin D3) calcitonin cholecystokinin (CCK) corticotropin-releasing hormone (CRH) cortisol dopamine erythropoietin (EPO) follicle stimulating hormone (FSH) gastrin glucagon gonadotropin-releasing |
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Anti-ageing, any real evidence - Here are some interesting facts to keep you up-to-date on some anti-ageing agents: DHEA: (Dehydroepiandrosterone) is a steroid secreted by the adrenal cortex. This hormone is the precursor for testosterone, progesterone and estrogen. This hormone is found to decline with age so replacing this hormone could be expected to slow age-related changes. DHEA has also been shown to be directly related to mortality with an inverse relationship exi... |
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