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Human growth hormone Human growth hormone (or hGH) is a polypeptide that is synthetised by somatotroph cells of the anterior lobe of pituitary gland. The genes for human growth hormone are localized in the q22-24 region of 17 chromosome and they are closely related to human chorionic sommatotropin (hCS) genes. The Insulin-like growth factor The insulin-like growth factors (IGF's) are polypeptides with high sequence similarity to insulin. They can trigger the same cellular responses as insulin, including mitogenesis in cell culture. IGF-II is thought to be a primary growth factor required for development while IGF-I expression is seen in later life. Gene knockout studies |
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