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    IGF-II is thought to be a primary growth factor required for development while IGF-I expression is seen in later life. Gene knockout studies in mice have confirmed this though other animals are likely to regulate the expression of these genes in distinct ways. While IGF-II may be primarily fetal in action it is also essential for development and function of organs such as the brain, liver and kidney. IGF-I is mainly secreted by the liver as a result of stimulation by Human Growth Hormone (hGH). Almost every cell in the human body is affected by IGF-I, especially cells in muscle, cartilage,



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