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IGF-II is thought to be a primary growth factor required for development while IGF-I expression is seen in later life. Gene knockout studies in mice have confirmed this though other animals are likely to regulate the expression of these genes in distinct ways. While IGF-II may be primarily fetal in action it is also essential for development and function of organs such as the brain, liver and kidney. IGF-I is mainly secreted by the liver as a result of stimulation by Human Growth Hormone (hGH). Almost every cell in the human body is affected by IGF-I, especially cells in muscle, cartilage, value. Every cell is capable of producing a vast number of regulatory molecules - tissue hormones, neurotransmitters, cytokines and many more. The classical endocrine glands and their hormone products are only better specialized to serve regulation on the overall organism level. Nevertheless they can in many instances be used in other ways or only on the tissue level. The most important hormones in humans include: adrenaline - synonymous with epinephrine adrenocorticotropic hormone (ACTH) aldosterone angiotensinogen antidiuretic hormone (ADH) atrial-natriuretic peptide (ANP) calciferol (vitamin D3) calcitonin cholecystokinin (CCK) corticotropin-releasing hormone (CRH) cortisol dopamine erythropoietin (EPO) follicle stimulating hormone (FSH) gastrin glucagon gonadotropin-releasing Human growth hormone Human growth hormone (or hGH) is a polypeptide that is synthetised by somatotroph cells of the anterior lobe of pituitary gland. The genes for human growth hormone are localized in the q22-24 region of 17 chromosome and they are closely related to human chorionic sommatotropin (hCS) genes. The hormone is built of single polypeptide Growth hormone Growth hormone (GH) also called Human growth hormone (hGH) is a polipeptide hormone responsible for growth and cell reproduction in a body. Released into blood stream every morning in decreasing amounts over age. The hormon is double the size of insulin and taken orally has no effect, except that the saliva can absorb about 5% of it. The growth Acromegaly Acromegaly (from Greek akros "high" and megalos "large" - extremities enlargement) is a is a hormonal disorder that results when the pituitary gland produces excess growth hormone (hGH). Most commonly it is a benign hGH producing tumor derived from a distinct type of cells (somatotrophs) and called pituitary adenoma. It most commonly affects middle-aged adults and can result in serious illness and premature death. In children the related |